Charge Neutralization of the Central Lysine Cluster in Prion Protein (PrP) Promotes PrP(Sc)-like Folding of Recombinant PrP Amyloids

The structure of the infectious form of prion protein, PrP(Sc), remains unclear. Most pure recombinant prion protein (PrP) amyloids generated in vitro are not infectious and lack the extent of the protease-resistant core and solvent exclusion of infectious PrP(Sc), especially within residues ∼90–160...

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Vydáno v:J Biol Chem
Hlavní autoři: Groveman, Bradley R., Kraus, Allison, Raymond, Lynne D., Dolan, Michael A., Anson, Kelsie J., Dorward, David W., Caughey, Byron
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294479/
https://ncbi.nlm.nih.gov/pubmed/25416779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619627
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