Charge Neutralization of the Central Lysine Cluster in Prion Protein (PrP) Promotes PrP(Sc)-like Folding of Recombinant PrP Amyloids

The structure of the infectious form of prion protein, PrP(Sc), remains unclear. Most pure recombinant prion protein (PrP) amyloids generated in vitro are not infectious and lack the extent of the protease-resistant core and solvent exclusion of infectious PrP(Sc), especially within residues ∼90–160...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Groveman, Bradley R., Kraus, Allison, Raymond, Lynne D., Dolan, Michael A., Anson, Kelsie J., Dorward, David W., Caughey, Byron
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294479/
https://ncbi.nlm.nih.gov/pubmed/25416779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619627
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