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Anti-PrP antibodies block PrP(Sc) replication in prion-infected cell cultures by accelerating PrP(C) degradation

The usage of anti-PrP antibodies represent one of the most promising strategy for the treatment of prion diseases. In the present study, we screened various anti-PrP antibodies, with the aim to identify those that will block PrP(Sc) replication in prion infected cell culture. Two antibodies, SAF34 r...

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Autores principales: Perrier, Véronique, Solassol, Jérôme, Crozet, Carole, Frobert, Yveline, Mourton-Gilles, Chantal, Grassi, Jacques, Lehmann, Sylvain
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063508/
https://ncbi.nlm.nih.gov/pubmed/15056288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2004.02356.x
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