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Inhibition of PrP(Sc) formation by lentiviral gene transfer of PrP containing dominant negative mutations
Currently there is no treatment to cure Transmissible Spongiform Encephalopathies. By taking advantage of the prion “resistant” polymorphisms Q171R and E219K that naturally exist in sheep and humans, respectively, we have evaluated a lentiviral gene transfer therapeutic approach. Here we show that V...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Company of Biologists
2004
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2062426/ https://ncbi.nlm.nih.gov/pubmed/15494372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.01484 |
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