Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrP(Sc)

Prion diseases are closely associated with the conversion of the cellular prion protein (PrP(C)) to an abnormal conformer (PrP(Sc)) [Prusiner, S. B. (1998) Proc. Natl. Acad. Sci. USA 95, 13363–13383]. Monoclonal antibodies that bind epitopes comprising residues 96–104 and 133–158 of PrP(C) potently...

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Autors principals: Moroncini, Gianluca, Kanu, Nnennaya, Solforosi, Laura, Abalos, Gil, Telling, Glenn C., Head, Mark, Ironside, James, Brockes, Jeremy P., Burton, Dennis R., Williamson, R. Anthony
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC478584/
https://ncbi.nlm.nih.gov/pubmed/15240877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403522101
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