Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrP(Sc)

Prion diseases are closely associated with the conversion of the cellular prion protein (PrP(C)) to an abnormal conformer (PrP(Sc)) [Prusiner, S. B. (1998) Proc. Natl. Acad. Sci. USA 95, 13363–13383]. Monoclonal antibodies that bind epitopes comprising residues 96–104 and 133–158 of PrP(C) potently...

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Main Authors: Moroncini, Gianluca, Kanu, Nnennaya, Solforosi, Laura, Abalos, Gil, Telling, Glenn C., Head, Mark, Ironside, James, Brockes, Jeremy P., Burton, Dennis R., Williamson, R. Anthony
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC478584/
https://ncbi.nlm.nih.gov/pubmed/15240877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403522101
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