Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrP(Sc)

Prion diseases are closely associated with the conversion of the cellular prion protein (PrP(C)) to an abnormal conformer (PrP(Sc)) [Prusiner, S. B. (1998) Proc. Natl. Acad. Sci. USA 95, 13363–13383]. Monoclonal antibodies that bind epitopes comprising residues 96–104 and 133–158 of PrP(C) potently...

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Bibliografiset tiedot
Päätekijät: Moroncini, Gianluca, Kanu, Nnennaya, Solforosi, Laura, Abalos, Gil, Telling, Glenn C., Head, Mark, Ironside, James, Brockes, Jeremy P., Burton, Dennis R., Williamson, R. Anthony
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2004
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC478584/
https://ncbi.nlm.nih.gov/pubmed/15240877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403522101
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