Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C)

The mammalian prions replicate by converting cellular prion protein (PrP(C)) into pathogenic conformational isoform (PrP(Sc)). Variations in prions, which cause different disease phenotypes, are referred to as strains. The mechanism of high-fidelity replication of prion strains in the absence of nuc...

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Detalhes bibliográficos
Main Authors: Kim, Chae, Haldiman, Tracy, Surewicz, Krystyna, Cohen, Yvonne, Chen, Wei, Blevins, Janis, Sy, Man-Sun, Cohen, Mark, Kong, Qingzhong, Telling, Glenn C., Surewicz, Witold K., Safar, Jiri G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410855/
https://ncbi.nlm.nih.gov/pubmed/22876179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002835
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