Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C)

The mammalian prions replicate by converting cellular prion protein (PrP(C)) into pathogenic conformational isoform (PrP(Sc)). Variations in prions, which cause different disease phenotypes, are referred to as strains. The mechanism of high-fidelity replication of prion strains in the absence of nuc...

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Autors principals: Kim, Chae, Haldiman, Tracy, Surewicz, Krystyna, Cohen, Yvonne, Chen, Wei, Blevins, Janis, Sy, Man-Sun, Cohen, Mark, Kong, Qingzhong, Telling, Glenn C., Surewicz, Witold K., Safar, Jiri G.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410855/
https://ncbi.nlm.nih.gov/pubmed/22876179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002835
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