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Protease-Sensitive Conformers in Broad Spectrum of Distinct PrP(Sc) Structures in Sporadic Creutzfeldt-Jakob Disease Are Indicator of Progression Rate
The origin, range, and structure of prions causing the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD), are largely unknown. To investigate the molecular mechanism responsible for the broad phenotypic variability of sCJD, we analyzed the conformational characteristics of p...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169556/ https://ncbi.nlm.nih.gov/pubmed/21931554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002242 |
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