Co-existence of Distinct Prion Types Enables Conformational Evolution of Human PrP(Sc) by Competitive Selection

The unique phenotypic characteristics of mammalian prions are thought to be encoded in the conformation of pathogenic prion proteins (PrP(Sc)). The molecular mechanism responsible for the adaptation, mutation, and evolution of prions observed in cloned cells and upon crossing the species barrier rem...

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Detalhes bibliográficos
Main Authors: Haldiman, Tracy, Kim, Chae, Cohen, Yvonne, Chen, Wei, Blevins, Janis, Qing, Liuting, Cohen, Mark L., Langeveld, Jan, Telling, Glenn C., Kong, Qingzhong, Safar, Jiri G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795283/
https://ncbi.nlm.nih.gov/pubmed/23974118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.500108
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