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The A53E α-Synuclein Pathological Mutation Demonstrates Reduced Aggregation Propensity in vitro and in Cell Culture

Mutations in the gene that encodes α-synuclein (αS) are a known cause of Parkinson's disease. αS is also the major component of pathological inclusions that characterize this disorder and a spectrum of other neurodegenerative diseases termed synucleinopathies. The effects of the most recently i...

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Detalhes bibliográficos
Publicado no:Neurosci Lett
Main Authors: Rutherford, Nicola J, Giasson, Benoit I
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476064/
https://ncbi.nlm.nih.gov/pubmed/25892596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2015.04.022
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