Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

BACKGROUND: Prior studies in C. elegans demonstrated that the expression of aggregation-prone polyglutamine proteins in muscle wall cells compromised the folding of co-expressed temperature-sensitive proteins, prompting interest in whether the accumulation of a misfolded protein in pathologic featur...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Pace, Michael C., Xu, Guilian, Fromholt, Susan, Howard, John, Giasson, Benoit I., Lewis, Jada, Borchelt, David R.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960184/
https://ncbi.nlm.nih.gov/pubmed/29776378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0253-9
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