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Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease
The deposition of pathologic misfolded proteins in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia and amyotrophic lateral sclerosis is hypothesized to burden protein homeostatic (proteostatic) machinery, potentially leading to insufficient capac...
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| Publicado no: | Acta Neuropathol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6411038/ https://ncbi.nlm.nih.gov/pubmed/30140941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1895-y |
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