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Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

Abstract A hallmark pathology of Alzheimer’s disease (AD) is the formation of amyloid β (Aβ) deposits that exhibit diverse localization and morphologies, ranging from diffuse to cored-neuritic deposits in brain parenchyma, with cerebral vascular deposition in leptomeningeal and parenchymal compartme...

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Detalhes bibliográficos
Main Authors: Guilian Xu, Susan E. Fromholt, Paramita Chakrabarty, Fanchao Zhu, Xuefei Liu, Michael C. Pace, Jin Koh, Todd E. Golde, Yona Levites, Jada Lewis, David R. Borchelt
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-04-01
Colecção:Acta Neuropathologica Communications
Acesso em linha:http://link.springer.com/article/10.1186/s40478-020-00911-y
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