Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition

Proinflammatory stimuli, after amyloid β (Aβ) deposition, have been hypothesized to create a self-reinforcing positive feedback loop that increases amyloidogenic processing of the Aβ precursor protein (APP), promoting further Aβ accumulation and neuroinflammation in Alzheimer’s disease (AD). Interle...

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Hlavní autoři: Chakrabarty, Paramita, Jansen-West, Karen, Beccard, Amanda, Ceballos-Diaz, Carolina, Levites, Yona, Verbeeck, Christophe, Zubair, Abba C., Dickson, Dennis, Golde, Todd E., Das, Pritam
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2010
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083918/
https://ncbi.nlm.nih.gov/pubmed/19825975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-141754
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