Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy

BACKGROUND: Microglial activation has been proposed to facilitate clearance of amyloid β protein (Aβ) from the brain following Aβ immunotherapy in amyloid precursor protein (APP) transgenic mice. Interleukin-1 receptor 1 knockout (IL-1 R1-/-) mice are reported to exhibit blunted inflammatory respons...

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Detalhes bibliográficos
Main Authors: Das, Pritam, Smithson, Lisa A, Price, Robert W, Holloway, Vallie M, Levites, Yona, Chakrabarty, Paramita, Golde, Todd E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1559596/
https://ncbi.nlm.nih.gov/pubmed/16872492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-3-17
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