Motor Neuron Loss and Neuroinflammation in a Model of α-Synuclein-induced Neurodegeneration

Mechanisms underlying α-synuclein (αSyn) mediated neurodegeneration are poorly understood. Intramuscular (IM) injection of αSyn fibrils in human A53T transgenic M83(+/−) mice produce a rapid model of α-synucleinopathy with highly predictable onset of motor impairment. Using varying doses of αSyn see...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Sorrentino, Zachary A, Xia, Yuxing, Funk, Cory, Riffe, Cara J, Rutherford, Nicola J, Ceballos Diaz, Carolina, Sacino, Amanda N, Price, Nathan D, Golde, Todd E, Giasson, Benoit I, Chakrabarty, Paramita
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6190709/
https://ncbi.nlm.nih.gov/pubmed/30195075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.09.005
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