Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates

por Nyborg, Andrew C, Ladd, Thomas B, Zwizinski, Craig W, Lah, James J, Golde, Todd E
Publicado em 2006

Designing antibodies against LRRK2-targeted tau epitopes

por Hamm, Matthew, Ladd, Thomas B., Levites, Yona, Golde, Todd E., Giasson, Benoit I., Lewis, Jada
Publicado no PLoS One (2018)

Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells

por Nyborg, Andrew C, Herl, Lauren, Berezovska, Oksana, Thomas, Anne V, Ladd, Thomas B, Jansen, Karen, Hyman, Bradley T, Golde, Todd E
Publicado em 2006

γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells

por Ran, Yong, Cruz, Pedro E., Ladd, Thomas B., Fauq, Abdul H., Jung, Joo In, Matthews, Julian, Felsenstein, Kevin M., Golde, Todd E.
Publicado em 2014

Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells

por Lessard, Christian B., Rodriguez, Edgardo, Ladd, Thomas B., Minter, Lisa M., Osborne, Barbara A., Miele, Lucio, Golde, Todd E., Ran, Yong
Publicado no J Biol Chem (2019)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

por Lessard, Christian B., Rodriguez, Edgardo, Ladd, Thomas B., Minter, Lisa M., Osborne, Barbara A., Miele, Lucio, Golde, Todd E., Ran, Yong
Publicado no Alzheimers Res Ther (2020)

Steroids as γ-secretase modulators

por Jung, Joo In, Ladd, Thomas B., Kukar, Thomas, Price, Ashleigh R., Moore, Brenda D., Koo, Edward H., Golde, Todd E., Felsenstein, Kevin M.
Publicado em 2013

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

por Jung, Joo In, Premraj, Sasha, Cruz, Pedro E., Ladd, Thomas B., Kwak, Yewon, Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E., Ran, Yong
Publicado em 2014

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice

por Rutherford, Nicola J., Sacino, Amanda N., Brooks, Mieu, Ceballos-Diaz, Carolina, Ladd, Thomas B., Howard, Jasie K., Golde, Todd E., Giasson, Benoit I.
Publicado no Mol Neurodegener (2015)

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators

por Jung, Joo In, Ran, Yong, Cruz, Pedro E., Rosario, Awilda M., Ladd, Thomas B., Kukar, Thomas L., Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E.
Publicado em 2014

Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains

por Moore, Brenda D, Chakrabarty, Paramita, Levites, Yona, Kukar, Tom L, Baine, Ann-Marie, Moroni, Tina, Ladd, Thomas B, Das, Pritam, Dickson, Dennis W, Golde, Todd E
Publicado em 2012

Retention in Endoplasmic Reticulum 1 (RER1) Modulates Amyloid-β (Aβ) Production by Altering Trafficking of γ-Secretase and Amyloid Precursor Protein (APP)

por Park, Hyo-Jin, Shabashvili, Daniil, Nekorchuk, Michael D., Shyqyriu, Eva, Jung, Joo In, Ladd, Thomas B., Moore, Brenda D., Felsenstein, Kevin M., Golde, Todd E., Kim, Seong-Hun
Publicado em 2012

APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model

por Deyts, Carole, Clutter, Mary, Pierce, Nicholas, Chakrabarty, Paramita, Ladd, Thomas B., Goddi, Anna, Rosario, Awilda M., Cruz, Pedro, Vetrivel, Kulandaivelu, Wagner, Steven L., Thinakaran, Gopal, Golde, Todd E., Parent, Angèle T.
Publicado no Cell Rep (2019)

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

por Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E
Publicado no EMBO Mol Med (2018)

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator

por Jung, Joo In, Price, Ashleigh R., Ladd, Thomas B., Ran, Yong, Park, Hyo-Jin, Ceballos-Diaz, Carolina, Smithson, Lisa A., Hochhaus, Günther, Tang, Yufei, Akula, Rajender, Ba, Saritha, Koo, Edward H., Shapiro, Gideon, Felsenstein, Kevin M., Golde, Todd E.
Publicado no Mol Neurodegener (2015)

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length: SUPPORT FOR A SEQUENTIAL MODEL OF γ-SECRETASE INTRAMEMBRANE PROTEOLYSIS AND...

por Kukar, Thomas L., Ladd, Thomas B., Robertson, Paul, Pintchovski, Sean A., Moore, Brenda, Bann, Maralyssa A., Ren, Zhao, Jansen-West, Karen, Malphrus, Kim, Eggert, Simone, Maruyama, Hiroko, Cottrell, Barbara A., Das, Pritam, Basi, Guriqbal S., Koo, Edward H., Golde, Todd E.
Publicado em 2011

Short Aβ peptides attenuate Aβ42 toxicity in vivo

por Moore, Brenda D., Martin, Jason, de Mena, Lorena, Sanchez, Jonatan, Cruz, Pedro E., Ceballos-Diaz, Carolina, Ladd, Thomas B., Ran, Yong, Levites, Yona, Kukar, Thomas L., Kurian, Justin J., McKenna, Robert, Koo, Edward H., Borchelt, David R., Janus, Christopher, Rincon-Limas, Diego, Fernandez-Funez, Pedro, Golde, Todd E.
Publicado no J Exp Med (2018)

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes

por Futch, Hunter S., McFarland, Karen N., Moore, Brenda D., Kuhn, M. Zino, Giasson, Benoit I., Ladd, Thomas B., Scott, Karen A., Shapiro, Melanie R., Nosacka, Rachel L., Goodwin, Marshall S., Ran, Yong, Cruz, Pedro E., Ryu, Daniel H., Croft, Cara L., Levites, Yona, Janus, Christopher, Chakrabarty, Paramita, Judge, Andrew R., Brusko, Todd M., de Kloet, Annette D., Krause, Eric G., Golde, Todd E.
Publicado no J Exp Med (2019)

Substrate-targeting γ-secretase modulators

por Kukar, Thomas L., Ladd, Thomas B., Bann, Maralyssa A., Fraering, Patrick C., Narlawar, Rajeshwar, Maharvi, Ghulam M., Healy, Brent, Chapman, Robert, Welzel, Alfred T., Price, Robert W., Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A., Torpey, Justin, Rosenberry, Terrone L., Fauq, Abdul, Wolfe, Michael S., Schmidt, Boris, Walsh, Dominic M., Koo, Edward H., Golde, Todd E.
Publicado em 2008

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease

por Chakrabarty, Paramita, Li, Andrew, Ladd, Thomas B., Strickland, Michael R., Koller, Emily J., Burgess, Jeremy D., Funk, Cory C., Cruz, Pedro E., Allen, Mariet, Yaroshenko, Mariya, Wang, Xue, Younkin, Curtis, Reddy, Joseph, Lohrer, Benjamin, Mehrke, Leonie, Moore, Brenda D., Liu, Xuefei, Ceballos-Diaz, Carolina, Rosario, Awilda M., Medway, Christopher, Janus, Christopher, Li, Hong-Dong, Dickson, Dennis W., Giasson, Benoit I., Price, Nathan D., Younkin, Steven G., Ertekin-Taner, Nilüfer, Golde, Todd E.
Publicado no J Exp Med (2018)