γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells

Understanding how different species of Aβ are generated by γ-secretase cleavage has broad therapeutic implications, because shifts in γ-secretase processing that increase the relative production of Aβx-42/43 can initiate a pathological cascade, resulting in Alzheimer disease. We have explored the se...

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Bibliographische Detailangaben
Hauptverfasser: Ran, Yong, Cruz, Pedro E., Ladd, Thomas B., Fauq, Abdul H., Jung, Joo In, Matthews, Julian, Felsenstein, Kevin M., Golde, Todd E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916530/
https://ncbi.nlm.nih.gov/pubmed/24352661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512921
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