Shifting a complex debate on γ-secretase cleavage and Alzheimer's disease

Yazar: Golde, Todd E, Ran, Yong, Felsenstein, Kevin M
Baskı/Yayın Bilgisi 2012

Regenerative Medicine in Alzheimer's Disease

Yazar: Felsenstein, Kevin M., Candelario, Kate M., Steindler, Dennis A., Borchelt, David R.
Baskı/Yayın Bilgisi 2013

γ-Secretase Inhibitors and Modulators

Yazar: Golde, Todd E., Koo, Edward H., Felsenstein, Kevin M., Osborne, Barbara A., Miele, Lucio
Baskı/Yayın Bilgisi 2013

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors

Yazar: Ran, Yong, Ladd, Gabriela Z., Ceballos-Diaz, Carolina, Jung, Joo In, Greenbaum, Doron, Felsenstein, Kevin M., Golde, Todd E.
Yayımlandı PLoS One (2015)

γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells

Yazar: Ran, Yong, Cruz, Pedro E., Ladd, Thomas B., Fauq, Abdul H., Jung, Joo In, Matthews, Julian, Felsenstein, Kevin M., Golde, Todd E.
Baskı/Yayın Bilgisi 2014

Steroids as γ-secretase modulators

Yazar: Jung, Joo In, Ladd, Thomas B., Kukar, Thomas, Price, Ashleigh R., Moore, Brenda D., Koo, Edward H., Golde, Todd E., Felsenstein, Kevin M.
Baskı/Yayın Bilgisi 2013

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

Yazar: Jung, Joo In, Premraj, Sasha, Cruz, Pedro E., Ladd, Thomas B., Kwak, Yewon, Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E., Ran, Yong
Baskı/Yayın Bilgisi 2014

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators

Yazar: Jung, Joo In, Ran, Yong, Cruz, Pedro E., Rosario, Awilda M., Ladd, Thomas B., Kukar, Thomas L., Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E.
Baskı/Yayın Bilgisi 2014

Retention in Endoplasmic Reticulum 1 (RER1) Modulates Amyloid-β (Aβ) Production by Altering Trafficking of γ-Secretase and Amyloid Precursor Protein (APP)

Yazar: Park, Hyo-Jin, Shabashvili, Daniil, Nekorchuk, Michael D., Shyqyriu, Eva, Jung, Joo In, Ladd, Thomas B., Moore, Brenda D., Felsenstein, Kevin M., Golde, Todd E., Kim, Seong-Hun
Baskı/Yayın Bilgisi 2012

Reversible Pathologic and Cognitive Phenotypes in an Inducible Model of Alzheimer-Amyloidosis

Yazar: Melnikova, Tatiana, Fromholt, Susan, Kim, HyunSu, Lee, Deidre, Xu, Guilian, Price, Ashleigh, Moore, Brenda D., Golde, Todd E., Felsenstein, Kevin M., Savonenko, Alena, Borchelt, David R.
Baskı/Yayın Bilgisi 2013

The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity

Yazar: Park, Hyo-Jin, Ran, Yong, Jung, Joo In, Holmes, Oliver, Price, Ashleigh R, Smithson, Lisa, Ceballos-Diaz, Carolina, Han, Chul, Wolfe, Michael S, Daaka, Yehia, Ryabinin, Andrey E, Kim, Seong-Hun, Hauger, Richard L, Golde, Todd E, Felsenstein, Kevin M
Yayımlandı EMBO J (2015)

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator

Yazar: Jung, Joo In, Price, Ashleigh R., Ladd, Thomas B., Ran, Yong, Park, Hyo-Jin, Ceballos-Diaz, Carolina, Smithson, Lisa A., Hochhaus, Günther, Tang, Yufei, Akula, Rajender, Ba, Saritha, Koo, Edward H., Shapiro, Gideon, Felsenstein, Kevin M., Golde, Todd E.
Yayımlandı Mol Neurodegener (2015)

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice

Yazar: Rogers, Kathryn, Felsenstein, Kevin M, Hrdlicka, Lori, Tu, Zhiming, Albayya, Faris, Lee, Winnie, Hopp, Sarah, Miller, Mary-Jo, Spaulding, Darcie, Yang, Zhiyong, Hodgdon, Hilliary, Nolan, Scott, Wen, Melody, Costa, Don, Blain, Jean-Francois, Freeman, Emily, De Strooper, Bart, Vulsteke, Veerle, Scrocchi, Louise, Zetterberg, Henrik, Portelius, Erik, Hutter-Paier, Birgit, Havas, Daniel, Ahlijanian, Michael, Flood, Dorothy, Leventhal, Liza, Shapiro, Gideon, Patzke, Holger, Chesworth, Richard, Koenig, Gerhard
Baskı/Yayın Bilgisi 2012