Retention in Endoplasmic Reticulum 1 (RER1) Modulates Amyloid-β (Aβ) Production by Altering Trafficking of γ-Secretase and Amyloid Precursor Protein (APP)

The presence of neuritic plaques containing aggregated amyloid-β (Aβ) peptides in the brain parenchyma is a pathological hallmark of Alzheimer disease (AD). Aβ is generated by sequential cleavage of the amyloid β precursor protein (APP) by β- and γ-secretase, respectively. As APP processing to Aβ re...

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Bibliographische Detailangaben
Hauptverfasser: Park, Hyo-Jin, Shabashvili, Daniil, Nekorchuk, Michael D., Shyqyriu, Eva, Jung, Joo In, Ladd, Thomas B., Moore, Brenda D., Felsenstein, Kevin M., Golde, Todd E., Kim, Seong-Hun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504776/
https://ncbi.nlm.nih.gov/pubmed/23043097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.418442
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