sAPP-α modulates β-secretase activity and amyloid-β generation

In sporadic age-related forms of Alzheimer’s disease (AD), it is unclear why amyloid-β (Aβ) peptides accumulate. Here, we show that soluble amyloid precursor protein-α (sAPP-α) decreases Aβ generation by directly associating with BACE1; thereby modulating APP processing. Whereas specifically targeti...

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Autori principali: Obregon, Demian, Hou, Huayan, Deng, Juan, Giunta, Brian, Tian, Jun, Darlington, Donna, Shahaduzzaman, MD, Zhu, Yuyuan, Mori, Takashi, Mattson, Mark P., Tan, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520614/
https://ncbi.nlm.nih.gov/pubmed/22491325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1781
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