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Soluble amyloid precursor protein alpha (sAPPα) inhibits tau phosphorylation through modulation of GSK3β signaling pathway

We recently found that sAPPα decreases Aβ generation by directly associating with β-site amyloid precursor protein (APP) converting enzyme 1 (BACE1), thereby modulating APP processing. Because inhibition of BACE1 decreases GSK3β-mediated Alzheimer’s disease (AD)-like tau phosphorylation in AD patien...

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書誌詳細
出版年:J Neurochem
主要な著者: Deng, Juan, Habib, Ahsan, Obregon, Demian F., Barger, Steven W., Giunta, Brian, Wang, Yan-Jiang, Hou, Huayan, Sawmiller, Darrell, Tan, Jun
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624213/
https://ncbi.nlm.nih.gov/pubmed/26342176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13351
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