Low density lipoprotein receptor-related protein-1 (LRP1) C4408R mutant promotes amyloid precursor protein (APP) α-cleavage in vitro

Previous studies have demonstrated that the low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) plays conflicting roles in Alzheimer’s disease (AD) pathogenesis, clearing β-amyloid (Aβ) from the brain while also enhancing APP endocytosis and resultant amyloidogenic processing. We have re...

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Detalhes bibliográficos
Publicado no:Neuromolecular Med
Main Authors: Hou, Huayan, Habib, Ahsan, Zi, Dan, Tian, Kathy, Tian, Jun, Giunta, Brian, Sawmiller, Darrell, Tan, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693694/
https://ncbi.nlm.nih.gov/pubmed/28612181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12017-017-8446-x
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