Human Cord Blood Serum-Derived APP α-Secretase Cleavage Activity is Mediated by C1 Complement

Alzheimer’s Disease (AD) is the leading cause of dementia in the elderly. In healthy individuals, amyloid precursor protein (APP) is cleaved by α-secretase, generating soluble α-amyloid precursor protein (sAPPα), which contributes neuroprotective functions in the neuronal environment. In contrast, i...

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Detalhes bibliográficos
Publicado no:Cell Transplant
Main Authors: Habib, Ahsan, Sawmiller, Darrell, Hou, Huayan, Kanithi, Manasa, Tian, Jun, Zeng, Jin, Zi, Dan, He, Zhi-Xu, Sanberg, Paul R., Tan, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020233/
https://ncbi.nlm.nih.gov/pubmed/29871524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0963689718775941
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