Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer’s mice

BACE1 initiates amyloid-β (Aβ) generation and the resultant cerebral amyloidosis, as a characteristic of Alzheimer’s disease (AD). Thus, inhibition of BACE1 has been the focus of a large body of research. The most recent clinical trials highlight the difficulty involved in this type of anti-AD thera...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Li, Song, Hou, Huayan, Mori, Takashi, Sawmiller, Darrell, Smith, Adam, Tian, Jun, Wang, Yanjiang, Giunta, Brian, Sanberg, Paul R., Zhang, Sheqing, Tan, Jun
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4473678/
https://ncbi.nlm.nih.gov/pubmed/26091071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11322
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