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Low density lipoprotein receptor-related protein-1 (LRP1) C4408R mutant promotes amyloid precursor protein (APP) α-cleavage in vitro
Previous studies have demonstrated that the low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) plays conflicting roles in Alzheimer’s disease (AD) pathogenesis, clearing β-amyloid (Aβ) from the brain while also enhancing APP endocytosis and resultant amyloidogenic processing. We have re...
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| Izdano u: | Neuromolecular Med |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693694/ https://ncbi.nlm.nih.gov/pubmed/28612181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12017-017-8446-x |
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