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A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition
BACKGROUND: The E4 isoform of apolipoprotein E (apoE4) is a major genetic risk factor for the development of sporadic Alzheimer’s disease (AD) and its modification has been an intense focus for treatment of AD in recent years. MEHTHODS: We investigated the binding of apoE, a peptide corresponding to...
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| Pubblicato in: | Biol Psychiatry |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6642011/ https://ncbi.nlm.nih.gov/pubmed/31208706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2019.04.026 |
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