A Novel Apolipoprotein E Antagonist Functionally Blocks Apolipoprotein E Interaction With N-terminal Amyloid Precursor Protein, Reduces β-Amyloid-Associated Pathology, and Improves Cognition

BACKGROUND: The E4 isoform of apolipoprotein E (apoE4) is a major genetic risk factor for the development of sporadic Alzheimer’s disease (AD) and its modification has been an intense focus for treatment of AD in recent years. MEHTHODS: We investigated the binding of apoE, a peptide corresponding to...

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Détails bibliographiques
Publié dans:Biol Psychiatry
Auteurs principaux: Sawmiller, Darrell, Habib, Ahsan, Hou, Huayan, Mori, Takashi, Fan, Anran, Tian, Jun, Zeng, Jin, Giunta, Brian, Sanberg, Paul R., Mattson, Mark P., Tan, Jun
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642011/
https://ncbi.nlm.nih.gov/pubmed/31208706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2019.04.026
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