Endoplasmic reticulum retention of the γ-secretase complex component Pen2 by Rer1

γ-Secretase is involved in the production of amyloid β-peptide, which is the principal component of amyloid plaques in the brains of patients with Alzheimer disease. γ-Secretase is a complex composed of presenilin (PS), nicastrin, anterior pharynx-defective phenotype 1 (Aph1) and PS enhancer 2 (Pen2...

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Detalhes bibliográficos
Main Authors: Kaether, Christoph, Scheuermann, Johanna, Fassler, Matthias, Zilow, Sonja, Shirotani, Keiro, Valkova, Christina, Novak, Bozidar, Kacmar, Slavomir, Steiner, Harald, Haass, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978084/
https://ncbi.nlm.nih.gov/pubmed/17668005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401027
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