Endoplasmic reticulum retention of the γ-secretase complex component Pen2 by Rer1

γ-Secretase is involved in the production of amyloid β-peptide, which is the principal component of amyloid plaques in the brains of patients with Alzheimer disease. γ-Secretase is a complex composed of presenilin (PS), nicastrin, anterior pharynx-defective phenotype 1 (Aph1) and PS enhancer 2 (Pen2...

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Sonraí Bibleagrafaíochta
Main Authors: Kaether, Christoph, Scheuermann, Johanna, Fassler, Matthias, Zilow, Sonja, Shirotani, Keiro, Valkova, Christina, Novak, Bozidar, Kacmar, Slavomir, Steiner, Harald, Haass, Christian
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2007
Ábhair:
Scientific Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978084/
https://ncbi.nlm.nih.gov/pubmed/17668005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401027
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