The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity

Lignende værker

• Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
  af: Edbauer, Dieter, et al.
  Udgivet: (2002)
• Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane
  af: Kaether, Christoph, et al.
  Udgivet: (2002)
• Chemical Cross-linking Provides a Model of the γ-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1
  af: Steiner, Harald, et al.
  Udgivet: (2008)
• Endoplasmic reticulum retention of the γ-secretase complex component Pen2 by Rer1
  af: Kaether, Christoph, et al.
  Udgivet: (2007)
• Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ(42) production
  af: Moehlmann, Tobias, et al.
  Udgivet: (2002)