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Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane

Amyloid β-peptide (Aβ) is generated by the consecutive cleavages of β- and γ-secretase. The intramembraneous γ-secretase cleavage critically depends on the activity of presenilins (PS1 and PS2). Although there is evidence that PSs are aspartyl proteases with γ-secretase activity, it remains controve...

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Main Authors: Kaether, Christoph, Lammich, Sven, Edbauer, Dieter, Ertl, Michaela, Rietdorf, Jens, Capell, Anja, Steiner, Harald, Haass, Christian
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173840/
https://ncbi.nlm.nih.gov/pubmed/12147673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200201123
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