Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ(42) production

The Alzheimer's disease (AD)-associated presenilin (PS) proteins are required for the γ-secretase cleavages of the β-amyloid precursor protein and the site 3 (S3) protease cleavage of Notch. These intramembrane cleavages release amyloid-β peptide (Aβ), including the pathogenic 42-aa variant (Aβ...

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Bibliographische Detailangaben
Hauptverfasser: Moehlmann, Tobias, Winkler, Edith, Xia, Xuefeng, Edbauer, Dieter, Murrell, Jill, Capell, Anja, Kaether, Christoph, Zheng, Hui, Ghetti, Bernardino, Haass, Christian, Steiner, Harald
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC123014/
https://ncbi.nlm.nih.gov/pubmed/12048239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.112686799
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