Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ(42) production

Eitemau Tebyg

• Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane
  gan: Kaether, Christoph, et al.
  Cyhoeddwyd: (2002)
• The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity
  gan: Kaether, Christoph, et al.
  Cyhoeddwyd: (2004)
• Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
  gan: Edbauer, Dieter, et al.
  Cyhoeddwyd: (2002)
• Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch
  gan: Kulic, Luka, et al.
  Cyhoeddwyd: (2000)
• Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
  gan: Sastre, Magdalena, et al.
  Cyhoeddwyd: (2001)