Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ(42) production

The Alzheimer's disease (AD)-associated presenilin (PS) proteins are required for the γ-secretase cleavages of the β-amyloid precursor protein and the site 3 (S3) protease cleavage of Notch. These intramembrane cleavages release amyloid-β peptide (Aβ), including the pathogenic 42-aa variant (Aβ(42))...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Moehlmann, Tobias, Winkler, Edith, Xia, Xuefeng, Edbauer, Dieter, Murrell, Jill, Capell, Anja, Kaether, Christoph, Zheng, Hui, Ghetti, Bernardino, Haass, Christian, Steiner, Harald
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123014/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12048239/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.112686799
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