Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ(42) production

Lignende værker

• Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane
  af: Kaether, Christoph, et al.
  Udgivet: (2002)
• The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity
  af: Kaether, Christoph, et al.
  Udgivet: (2004)
• Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
  af: Edbauer, Dieter, et al.
  Udgivet: (2002)
• Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch
  af: Kulic, Luka, et al.
  Udgivet: (2000)
• Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
  af: Sastre, Magdalena, et al.
  Udgivet: (2001)