Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch

Most of the genetically inherited Alzheimer's disease cases are caused by mutations in the presenilin genes, PS1 and PS2. PS mutations result in the enhanced production of the highly amyloidogenic 42/43 amino acid variant of amyloid β-peptide (Aβ). We have introduced arbitrary mutations at position...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kulic, Luka, Walter, Jochen, Multhaup, Gerd, Teplow, David B., Baumeister, Ralf, Romig, Helmut, Capell, Anja, Steiner, Harald, Haass, Christian
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18533/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10811883/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.100049897
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