Insulin-like Growth Factor-1 (IGF-1)-induced Processing of Amyloid-β Precursor Protein (APP) and APP-like Protein 2 Is Mediated by Different Metalloproteinases

Por Jacobsen, Kristin T., Adlerz, Linda, Multhaup, Gerd, Iverfeldt, Kerstin
Publicado em 2010

Disturbed Copper Bioavailability in Alzheimer's Disease

Por Kaden, Daniela, Bush, Ashley I., Danzeisen, Ruth, Bayer, Thomas A., Multhaup, Gerd
Publicado em 2011

Receptor recognition by a hepatitis B virus reveals a novel mode of high affinity virus–receptor interaction

Por Urban, Stephan, Schwarz, Caroline, Marx, Ute C., Zentgraf, Hanswalter, Schaller, Heinz, Multhaup, Gerd
Publicado em 2000

Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes

Por Dahms, Sven O., Mayer, Magnus C., Roeser, Dirk, Multhaup, Gerd, Than, Manuel E.
Publicado no Acta Crystallogr D Biol Crystallogr (2015)

Structural and Mechanistic Implications of Metal Binding in the Small Heat-shock Protein αB-crystallin

Por Mainz, Andi, Bardiaux, Benjamin, Kuppler, Frank, Multhaup, Gerd, Felli, Isabella C., Pierattelli, Roberta, Reif, Bernd
Publicado em 2012

Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc

Por Yepiskoposyan, Hasmik, Egli, Dieter, Fergestad, Tim, Selvaraj, Anand, Treiber, Carina, Multhaup, Gerd, Georgiev, Oleg, Schaffner, Walter
Publicado em 2006

Suppression of Amyloid β A11 Antibody Immunoreactivity by Vitamin C: POSSIBLE ROLE OF HEPARAN SULFATE OLIGOSACCHARIDES DERIVED FROM GLYPICAN-1 BY ASCORBATE-INDUCED, NITRIC OXIDE (N...

Por Cheng, Fang, Cappai, Roberto, Ciccotosto, Giuseppe D., Svensson, Gabriel, Multhaup, Gerd, Fransson, Lars-Åke, Mani, Katrin
Publicado em 2011

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

Por Isbert, Simone, Wagner, Katja, Eggert, Simone, Schweitzer, Andrea, Multhaup, Gerd, Weggen, Sascha, Kins, Stefan, Pietrzik, Claus U.
Publicado em 2011

Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

Por Sastre, Magdalena, Steiner, Harald, Fuchs, Klaus, Capell, Anja, Multhaup, Gerd, Condron, Margaret M., Teplow, David B., Haass, Christian
Publicado em 2001

Aberrant Amyloid Precursor Protein (APP) Processing in Hereditary Forms of Alzheimer Disease Caused by APP Familial Alzheimer Disease Mutations Can Be Rescued by Mutations in the A...

Por Munter, Lisa-Marie, Botev, Anne, Richter, Luise, Hildebrand, Peter W., Althoff, Veit, Weise, Christoph, Kaden, Daniela, Multhaup, Gerd
Publicado em 2010

Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch

Por Kulic, Luka, Walter, Jochen, Multhaup, Gerd, Teplow, David B., Baumeister, Ralf, Romig, Helmut, Capell, Anja, Steiner, Harald, Haass, Christian
Publicado em 2000

Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions

Por Olsson, Fredrik, Schmidt, Staffan, Althoff, Veit, Munter, Lisa M., Jin, Shaobo, Rosqvist, Susanne, Lendahl, Urban, Multhaup, Gerd, Lundkvist, Johan
Publicado em 2014

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

Por Bien, Jessica, Jefferson, Tamara, Čaušević, Mirsada, Jumpertz, Thorsten, Munter, Lisa, Multhaup, Gerd, Weggen, Sascha, Becker-Pauly, Christoph, Pietrzik, Claus U.
Publicado em 2012

The Heat Shock Response Is Modulated by and Interferes with Toxic Effects of Scrapie Prion Protein and Amyloid β

Por Resenberger, Ulrike K., Müller, Veronika, Munter, Lisa M., Baier, Michael, Multhaup, Gerd, Wilson, Mark R., Winklhofer, Konstanze F., Tatzelt, Jörg
Publicado em 2012

The Proton-Pump Inhibitor Lansoprazole Enhances Amyloid Beta Production

Por Badiola, Nahuai, Alcalde, Victor, Pujol, Albert, Münter, Lisa-Marie, Multhaup, Gerd, Lleó, Alberto, Coma, Mireia, Soler-López, Montserrat, Aloy, Patrick
Publicado em 2013

Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

Por Tienari, Pentti J., Ida, Nobuo, Ikonen, Elina, Simons, Mikael, Weidemann, Andreas, Multhaup, Gerd, Masters, Colin L., Dotti, Carlos G., Beyreuther, Konrad
Publicado em 1997

Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization

Por Liebsch, Filip, Aurousseau, Mark R. P., Bethge, Tobias, McGuire, Hugo, Scolari, Silvia, Herrmann, Andreas, Blunck, Rikard, Bowie, Derek, Multhaup, Gerd
Publicado no J Biol Chem (2017)

A Family Knockout of All Four Drosophila Metallothioneins Reveals a Central Role in Copper Homeostasis and Detoxification

Por Egli, Dieter, Yepiskoposyan, Hasmik, Selvaraj, Anand, Balamurugan, Kuppusamy, Rajaram, Rama, Simons, Andreas, Multhaup, Gerd, Mettler, Simone, Vardanyan, Alla, Georgiev, Oleg, Schaffner, Walter
Publicado em 2006

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42

Por Munter, Lisa-Marie, Voigt, Philipp, Harmeier, Anja, Kaden, Daniela, Gottschalk, Kay E, Weise, Christoph, Pipkorn, Rüdiger, Schaefer, Michael, Langosch, Dieter, Multhaup, Gerd
Publicado em 2007

Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide

Por Prade, Elke, Bittner, Heiko J., Sarkar, Riddhiman, Lopez del Amo, Juan Miguel, Althoff-Ospelt, Gerhard, Multhaup, Gerd, Hildebrand, Peter W., Reif, Bernd
Publicado no J Biol Chem (2015)