Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

Cerebral plaques containing β-amyloid (βA4) represent an invariant pathological feature of Alzheimer disease (AD). βA4 is proteolytically generated from its parent molecule, amyloid precursor protein (APP). In nonneuronal cells βA4 has been shown to be secreted via a pH-sensitive and endocytosis-dep...

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Detalhes bibliográficos
Main Authors: Tienari, Pentti J., Ida, Nobuo, Ikonen, Elina, Simons, Mikael, Weidemann, Andreas, Multhaup, Gerd, Masters, Colin L., Dotti, Carlos G., Beyreuther, Konrad
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20579/
https://ncbi.nlm.nih.gov/pubmed/9108116
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