Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

Cerebral plaques containing β-amyloid (βA4) represent an invariant pathological feature of Alzheimer disease (AD). βA4 is proteolytically generated from its parent molecule, amyloid precursor protein (APP). In nonneuronal cells βA4 has been shown to be secreted via a pH-sensitive and endocytosis-dep...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Tienari, Pentti J., Ida, Nobuo, Ikonen, Elina, Simons, Mikael, Weidemann, Andreas, Multhaup, Gerd, Masters, Colin L., Dotti, Carlos G., Beyreuther, Konrad
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108116/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.4125
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!