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Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.

A distinguishing feature of Alzheimer's disease (AD) is the deposition of amyloid plaques in brain parenchyma. These plaques arise by the abnormal accumulation of beta A4, a proteolytic fragment of amyloid precursor protein (APP). Despite the fact that neurons are dramatically affected in the c...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: De Strooper, B, Simons, M, Multhaup, G, Van Leuven, F, Beyreuther, K, Dotti, C G
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1995
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC394596/
https://ncbi.nlm.nih.gov/pubmed/7588622
Etiketak: Etiketa erantsi
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