Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.

A distinguishing feature of Alzheimer's disease (AD) is the deposition of amyloid plaques in brain parenchyma. These plaques arise by the abnormal accumulation of beta A4, a proteolytic fragment of amyloid precursor protein (APP). Despite the fact that neurons are dramatically affected in the course...

Полное описание

Библиографические подробности

Опубликовано в::	EMBO J
Главные авторы:	De Strooper, B, Simons, M, Multhaup, G, Van Leuven, F, Beyreuther, K, Dotti, C G
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 1995
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394596/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7588622/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb00176.x
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!