Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.

A distinguishing feature of Alzheimer's disease (AD) is the deposition of amyloid plaques in brain parenchyma. These plaques arise by the abnormal accumulation of beta A4, a proteolytic fragment of amyloid precursor protein (APP). Despite the fact that neurons are dramatically affected in the c...

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Bibliographic Details
Published in:EMBO J
Main Authors: De Strooper, B, Simons, M, Multhaup, G, Van Leuven, F, Beyreuther, K, Dotti, C G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1995
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394596/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7588622/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb00176.x
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