The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.

We have analysed the axonal sorting signals of amyloid precursor protein (APP). Wild-type and mutant versions of human APP were expressed in hippocampal neurons using the Semliki forest virus system. We show that wild-type APP and mutations implicated in Alzheimer's disease and another brain be...

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Detalhes bibliográficos
Main Authors: Tienari, P J, De Strooper, B, Ikonen, E, Simons, M, Weidemann, A, Czech, C, Hartmann, T, Ida, N, Multhaup, G, Masters, C L, Van Leuven, F, Beyreuther, K, Dotti, C G
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC452266/
https://ncbi.nlm.nih.gov/pubmed/8895567
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