The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.

We have analysed the axonal sorting signals of amyloid precursor protein (APP). Wild-type and mutant versions of human APP were expressed in hippocampal neurons using the Semliki forest virus system. We show that wild-type APP and mutations implicated in Alzheimer's disease and another brain beta-am...

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Detalles Bibliográficos

Publicado en:	EMBO J
Autores principales:	Tienari, P J, De Strooper, B, Ikonen, E, Simons, M, Weidemann, A, Czech, C, Hartmann, T, Ida, N, Multhaup, G, Masters, C L, Van Leuven, F, Beyreuther, K, Dotti, C G
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452266/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8895567/
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