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Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

Abstract Background Despite diverging levels of amyloid-β (Aβ) and TAU pathology, different mouse models, as well as sporadic AD patients show predictable patterns of episodic memory loss. MicroRNA (miRNA) deregulation is well established in AD brain but it is unclear whether Aβ or TAU pathology dri...

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Principais autores: Annerieke Sierksma, Ashley Lu, Evgenia Salta, Elke Vanden Eynden, Zsuzsanna Callaerts-Vegh, Rudi D’Hooge, David Blum, Luc Buée, Mark Fiers, Bart De Strooper
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-10-01
Serier:Molecular Neurodegeneration
Fag:
Alzheimer’s disease
microRNA
miRNA-seq
In situ hybridization
miR-mimic
Online adgang:http://link.springer.com/article/10.1186/s13024-018-0285-1
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