Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

Cerebral plaques containing β-amyloid (βA4) represent an invariant pathological feature of Alzheimer disease (AD). βA4 is proteolytically generated from its parent molecule, amyloid precursor protein (APP). In nonneuronal cells βA4 has been shown to be secreted via a pH-sensitive and endocytosis-dep...

Descrición completa

Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Tienari, Pentti J., Ida, Nobuo, Ikonen, Elina, Simons, Mikael, Weidemann, Andreas, Multhaup, Gerd, Masters, Colin L., Dotti, Carlos G., Beyreuther, Konrad
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108116/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.4125
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!