Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

Cerebral plaques containing β-amyloid (βA4) represent an invariant pathological feature of Alzheimer disease (AD). βA4 is proteolytically generated from its parent molecule, amyloid precursor protein (APP). In nonneuronal cells βA4 has been shown to be secreted via a pH-sensitive and endocytosis-dep...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Tienari, Pentti J., Ida, Nobuo, Ikonen, Elina, Simons, Mikael, Weidemann, Andreas, Multhaup, Gerd, Masters, Colin L., Dotti, Carlos G., Beyreuther, Konrad
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1997
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9108116/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.8.4125
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