The Heat Shock Response Is Modulated by and Interferes with Toxic Effects of Scrapie Prion Protein and Amyloid β

The heat shock response (HSR) is an evolutionarily conserved pathway designed to maintain proteostasis and to ameliorate toxic effects of aberrant protein folding. We have studied the modulation of the HSR by the scrapie prion protein (PrP(Sc)) and amyloid β peptide (Aβ) and investigated whether an...

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Détails bibliographiques
Auteurs principaux: Resenberger, Ulrike K., Müller, Veronika, Munter, Lisa M., Baier, Michael, Multhaup, Gerd, Wilson, Mark R., Winklhofer, Konstanze F., Tatzelt, Jörg
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527961/
https://ncbi.nlm.nih.gov/pubmed/23115236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.389007
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