The Heat Shock Response Is Modulated by and Interferes with Toxic Effects of Scrapie Prion Protein and Amyloid β

The heat shock response (HSR) is an evolutionarily conserved pathway designed to maintain proteostasis and to ameliorate toxic effects of aberrant protein folding. We have studied the modulation of the HSR by the scrapie prion protein (PrP(Sc)) and amyloid β peptide (Aβ) and investigated whether an...

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Hlavní autoři: Resenberger, Ulrike K., Müller, Veronika, Munter, Lisa M., Baier, Michael, Multhaup, Gerd, Wilson, Mark R., Winklhofer, Konstanze F., Tatzelt, Jörg
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527961/
https://ncbi.nlm.nih.gov/pubmed/23115236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.389007
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