The Heat Shock Response Is Modulated by and Interferes with Toxic Effects of Scrapie Prion Protein and Amyloid β

The heat shock response (HSR) is an evolutionarily conserved pathway designed to maintain proteostasis and to ameliorate toxic effects of aberrant protein folding. We have studied the modulation of the HSR by the scrapie prion protein (PrP(Sc)) and amyloid β peptide (Aβ) and investigated whether an...

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Bibliografiske detaljer
Main Authors: Resenberger, Ulrike K., Müller, Veronika, Munter, Lisa M., Baier, Michael, Multhaup, Gerd, Wilson, Mark R., Winklhofer, Konstanze F., Tatzelt, Jörg
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527961/
https://ncbi.nlm.nih.gov/pubmed/23115236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.389007
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