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Association of Bcl-2 with Misfolded Prion Protein Is Linked to the Toxic Potential of Cytosolic PrP

Protein misfolding is linked to different neurodegenerative disorders like Alzheimer’s disease, polyglutamine, and prion diseases. We investigated the cytotoxic effects of aberrant conformers of the prion protein (PrP) and show that toxicity is specifically linked to misfolding of PrP in the cytosol...

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Библиографические подробности
Главные авторы: Rambold, Angelika S., Miesbauer, Margit, Rapaport, Doron, Bartke, Till, Baier, Michael, Winklhofer, Konstanze F., Tatzelt, Jörg
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Cell Biology 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1525242/
https://ncbi.nlm.nih.gov/pubmed/16707568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-01-0083
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