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Association of Bcl-2 with Misfolded Prion Protein Is Linked to the Toxic Potential of Cytosolic PrP

Protein misfolding is linked to different neurodegenerative disorders like Alzheimer’s disease, polyglutamine, and prion diseases. We investigated the cytotoxic effects of aberrant conformers of the prion protein (PrP) and show that toxicity is specifically linked to misfolding of PrP in the cytosol...

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Detalhes bibliográficos
Main Authors: Rambold, Angelika S., Miesbauer, Margit, Rapaport, Doron, Bartke, Till, Baier, Michael, Winklhofer, Konstanze F., Tatzelt, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1525242/
https://ncbi.nlm.nih.gov/pubmed/16707568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-01-0083
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