Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrP(C)) in Alzheimer’s disease

The cellular prion protein (PrP(C)) is implicated in neuroprotective signaling and neurotoxic pathways in both prion diseases and Alzheimer’s disease (AD). Specifically, the intrinsically disordered N-terminal domain (N-PrP) has been shown to interact with neurotoxic ligands, such as Aβ and Scrapie...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ulbrich, Sarah, Janning, Petra, Seidel, Ralf, Matschke, Jakob, Gonsberg, Anika, Jung, Sebastian, Glatzel, Markus, Engelhard, Martin, Winklhofer, Konstanze F., Tatzelt, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5965872/
https://ncbi.nlm.nih.gov/pubmed/29791485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197659
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