Dimerization of the cellular prion protein inhibits propagation of scrapie prions

A central step in the pathogenesis of prion diseases is the conformational transition of the cellular prion protein (PrP(C)) into the scrapie isoform, denoted PrP(Sc). Studies in transgenic mice have indicated that this conversion requires a direct interaction between PrP(C) and PrP(Sc); however, in...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Engelke, Anna D., Gonsberg, Anika, Thapa, Simrika, Jung, Sebastian, Ulbrich, Sarah, Seidel, Ralf, Basu, Shaon, Multhaup, Gerd, Baier, Michael, Engelhard, Martin, Schätzl, Hermann M., Winklhofer, Konstanze F., Tatzelt, Jörg
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971439/
https://ncbi.nlm.nih.gov/pubmed/29636413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000990
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