Dimerization of the cellular prion protein inhibits propagation of scrapie prions

A central step in the pathogenesis of prion diseases is the conformational transition of the cellular prion protein (PrP(C)) into the scrapie isoform, denoted PrP(Sc). Studies in transgenic mice have indicated that this conversion requires a direct interaction between PrP(C) and PrP(Sc); however, in...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Engelke, Anna D., Gonsberg, Anika, Thapa, Simrika, Jung, Sebastian, Ulbrich, Sarah, Seidel, Ralf, Basu, Shaon, Multhaup, Gerd, Baier, Michael, Engelhard, Martin, Schätzl, Hermann M., Winklhofer, Konstanze F., Tatzelt, Jörg
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971439/
https://ncbi.nlm.nih.gov/pubmed/29636413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000990
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