Dimerization of the cellular prion protein inhibits propagation of scrapie prions

A central step in the pathogenesis of prion diseases is the conformational transition of the cellular prion protein (PrP(C)) into the scrapie isoform, denoted PrP(Sc). Studies in transgenic mice have indicated that this conversion requires a direct interaction between PrP(C) and PrP(Sc); however, in...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Engelke, Anna D., Gonsberg, Anika, Thapa, Simrika, Jung, Sebastian, Ulbrich, Sarah, Seidel, Ralf, Basu, Shaon, Multhaup, Gerd, Baier, Michael, Engelhard, Martin, Schätzl, Hermann M., Winklhofer, Konstanze F., Tatzelt, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971439/
https://ncbi.nlm.nih.gov/pubmed/29636413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000990
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