Dimerization of the cellular prion protein inhibits propagation of scrapie prions

A central step in the pathogenesis of prion diseases is the conformational transition of the cellular prion protein (PrP(C)) into the scrapie isoform, denoted PrP(Sc). Studies in transgenic mice have indicated that this conversion requires a direct interaction between PrP(C) and PrP(Sc); however, in...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Engelke, Anna D., Gonsberg, Anika, Thapa, Simrika, Jung, Sebastian, Ulbrich, Sarah, Seidel, Ralf, Basu, Shaon, Multhaup, Gerd, Baier, Michael, Engelhard, Martin, Schätzl, Hermann M., Winklhofer, Konstanze F., Tatzelt, Jörg
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971439/
https://ncbi.nlm.nih.gov/pubmed/29636413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000990
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