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Dimerization of the cellular prion protein inhibits propagation of scrapie prions
A central step in the pathogenesis of prion diseases is the conformational transition of the cellular prion protein (PrP(C)) into the scrapie isoform, denoted PrP(Sc). Studies in transgenic mice have indicated that this conversion requires a direct interaction between PrP(C) and PrP(Sc); however, in...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5971439/ https://ncbi.nlm.nih.gov/pubmed/29636413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000990 |
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