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Dimerization of the cellular prion protein inhibits propagation of scrapie prions
A central step in the pathogenesis of prion diseases is the conformational transition of the cellular prion protein (PrP(C)) into the scrapie isoform, denoted PrP(Sc). Studies in transgenic mice have indicated that this conversion requires a direct interaction between PrP(C) and PrP(Sc); however, in...
Guardat en:
| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5971439/ https://ncbi.nlm.nih.gov/pubmed/29636413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000990 |
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