α-Helical Domains Promote Translocation of Intrinsically Disordered Polypeptides into the Endoplasmic Reticulum

Co-translational import into the endoplasmic reticulum (ER) is primarily controlled by N-terminal signal sequences that mediate targeting of the ribosome-nascent chain complex to the Sec61/translocon and initiate the translocation process. Here we show that after targeting to the translocon the seco...

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Détails bibliographiques
Auteurs principaux: Miesbauer, Margit, Pfeiffer, Natalie V., Rambold, Angelika S., Müller, Veronika, Kiachopoulos, Sophia, Winklhofer, Konstanze F., Tatzelt, Jörg
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Protein Synthesis, Post-Translational Modification, and Degradation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782031/
https://ncbi.nlm.nih.gov/pubmed/19561072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023135
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